Endocrine Abstracts

Objective: The red blood cell distribution width (RDW) is being recognized as a global marker of chronic inflammation, high level of oxidative stress, and cardiovascular disease risk. We aimed to investigate the relation between the level of RDW and highly sensitive C-reactive protein (hs-CRP), insulin resistance, BMI and body fat percentage in women with polycystic ovary syndrome (PCOS).Methods: Cross-sectional study of 90 PCOS (2003 Rotterdam Consensus...

Background: We aimed prospectively investigate the laboratory and electrocardiographic parameters (hearth rate, QRS, QT, QTc, Tpe, Tpe/QTc, arrhythmia prevalance) in patients with graves disease before and after antithyroid therapy.Methods: 71 patients (48 female, 23 male), age between 18–50 (mean ± s.d.: 36.48 ± 12.20) with GD were included into the study. Patients treated with antithyroid therapy (thionamids and/or surgical the...

Aim: The incidence of nodular thyroid disease is high among patients with insulin resistance. The aim of this study is to evaluate the relationship between BRAFV600E mutation and insulin resistance in the patients with papillary thyroid cancer.Materials and methods: We examined clinical and laboratory data of 103 patients who had been followed up by our department between the years 2010 and 2015. The diagnosis of insulin resistance (IR) was made when the...

Introduction: Wolfram syndrome has characterized by central diabetes insipidus (DI), diabetes mellitus (DM), optic atrophy (OA) and deafness. In this report we presented a Wolfram syndrome with hypergonadotropic hypogonadism.Case: A 18-year-old girl who has diabetes for 6 years was hospitalized due to blood sugar irregularity. Her medical history revealed frequent urination and enuresis for 2–3 years and primary amenorrhea. Furthermore she had hear ...

Introduction: The most common cause of diabetes insipidus is idiopathic. However, it may be also seen after metastasis to hypothalamic–pituitary region.Case: Fifty year old female patient with breast cancer was referred to our clinic with complaints of polyuria and polydipsia. Two years ago, she had diagnosed and after surgery, she has taken three cycles of cyclophosphamide+adriamycin+5-flurourasil than three cycles dosetaxel and finally seventeen c...

Aim: The aim of this study was to examine serum fetuin-A, leptin and hs-CRP concentrations among pregnant women with gestational diabetes (GDM), and to evaluate the relationship between these parameters and insulin resistance.Materials and methods: In this study, we evaluated 47 pregnant patients with GDM. As the control group, 43 normal pregnant women having similar properties with these GDM patients, but not gestational diabetes were enrolled. Serum fe...

Aim: BRAF is one of the serine threonin kinases that activates mitogen activated protein kinase (MAPK) signal pathway.The aim of this study is to evaluatethe relationship between extrathyroidal extension (ETE) and BRAFV600E mutation in the subjects with papillary thyroid cancer.Materials and methods: Clinical and laboratory data of 455 patients, who had been followed-up in our clinic between the years 2010 and 2015 for PTC, were evaluated. The relationsh...

Context: Betatrophin is a newly identified hormone appreciated for its role as a potent inducer of beta cell proliferation in line with insulin resistance in mice. Polycystic ovary syndrome (PCOS) is an inflammatory-based metabolic disease associated with insulin resistance. However, no evidence was available whether betatrophin is involved in women with PCOS.Objective: To ascertain whether betatrophin levels are altered in women with PCOS.<p class="...